Collagen fibril formation during embryogenesis.
نویسندگان
چکیده
منابع مشابه
Collagen Fibril Formation
Soluble rat tail tendon collagen with intact nonhelical ends and largely free of aggregates was used to study fibril formation in vitro. The process was initiated by raising the pH and warming a cold solution of collagen. Fibril formation was monitored by turbidity and the product was examined by electron microscopy. Optimal conditions that will form fibrils similar to those observed in vivo ar...
متن کاملCollagen fibril formation.
Collagen is most abundant in animal tissues as very long fibrils with a characteristic axial periodic structure. The fibrils provide the major biomechanical scaffold for cell attachment and anchorage of macromolecules, allowing the shape and form of tissues to be defined and maintained. How the fibrils are formed from their monomeric precursors is the primary concern of this review. Collagen fi...
متن کاملCollagen Fibril Formation in Vitro
We showed previously that fibril formation in vitro from rat tail tendon collagen requires a temperaturedependent initiation (Step 1) following which linear assembly to form thin filaments (Step 2) proceeds as rapidly at 4°C as at 26°C. Step 3, lateral assembly of filaments to form fibrils, is again temperature-dependent. We now find that Step 1 is complete in 6 min at 26°C and the time is inde...
متن کاملInhibition of collagen fibril formation
BACKGROUND The overall aim of presented study is to test the inhibition of the formation of collagen fibrils as the novel approach to reduce accumulation of pathological fibrotic deposits. The main hypothesis is that by interfering with the initial steps of the extracellular process of collagen fibril formation, it is possible to reduce the formation of fibrotic tissue. METHODS The experiment...
متن کاملCollagen Fibril Formation at Microgravity Conditions:
Collagen molecules can selfassemble from dilute solutions into axially ordered fibrils similar to those seen in vivo in tendon and skin. At neutral pH the self-assembly has a negative temperature coefficient, thus molecules can be held in solution at 4-15 C; a temperature jump to 25-30 C will then lead to fibrillogenesis under controlled conditions. Two experiments have been carried out under...
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ژورنال
عنوان ژورنال: Proceedings of the National Academy of Sciences
سال: 1983
ISSN: 0027-8424,1091-6490
DOI: 10.1073/pnas.80.11.3354